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BIOLOGICAL SAMPLE PREPARATION

Tissue preparation and cell disruption.
Choose your approach.

Explore French Press systems, bead beaters, mixer mills, ultrasonic processors, rotor-stator homogenizers, cryogenic grinders and pulverizers, tissue clamps and manual macerators. Match the equipment to your sample, preparation method and downstream goals.

Glen Mills French Press G-M Model 11 Cell Disruptor for breaking cells using high pressure; cell disruptor with hydraulic piston and pressure gauge
Not sure which option fits your work?Use the practical selection helper ↗

A PRACTICAL SELECTION HELPER

Find a practical starting point.

Choose a task, then answer four essential questions to find a starting point. Leave anything you don’t know blank or select “Not sure yet”.

All options in this helper (21)
French Press ↗

High-pressure mechanical lysis with standard and mini-cell choices.

Standard cell reference: 35 mL / 40 kpsi; confirm working loading

MM 400 Mixer Mill ↗

Bead beating with compatible reaction-vial adapters; other jar and tube formats need configuration review.

Vial count depends on the selected adapter

MM 500 Mixer Mill Vario ↗

Parallel biological preparations with compatible vial adapters; count depends on the vessel format.

Vial count depends on the selected adapter

Mini-Beadbeater-Plus ↗

A compact bead mill for individual biological samples in sealed screw-cap microvials, with digital timing and a brushless motor.

Sample capacity: 10-400 mg wet weight · Vial format: One 2 mL screw-cap microvial

Mini-BeadBeater-16 ULTRA ↗

A compact 16-position bead mill for microbial cells and plant or animal tissue, with digital timing and a quiet ULTRA enclosure.

Vial positions: Up to 16 × 2 mL screw-cap microvials · Speed: 3,450 rpm

Mini-BeadBeater-24 ULTRA ↗

A 24-position bead mill for biological sample disruption, with variable speed, runtime cycling and a quiet ULTRA enclosure.

Vial positions: Up to 24 × 2 mL screw-cap microvials · Speed: 2,400-3,800 rpm

Mini-Beadbeater-96 ↗

A high-capacity bead mill for parallel disruption of biological samples in deep-well plates, microvials or larger tubes.

Plate capacity: One 2 mL deep-well plate or two 1 mL deep-well plates · Tube formats: 45 microvials; optional holders for twenty 7 mL or two 50 mL tubes

BeadBeater ↗

A chamber-style bead mill for disrupting aqueous suspensions of yeast, fungi and bacteria for protein, enzyme and organelle recovery.

Chamber volume: 350 mL total; 200 mL working · Motor: 3/8 hp, single speed

BioPulverizer ↗

A stainless steel mortar and pestle system for fragmenting hard-frozen tissue before extraction or further homogenization.

Single-sample options: 10–100 mg, 0.1–1 g or 1–10 g · 12-well option: 10–100 mg per well

CryoCup Grinder II ↗

An insulated stainless steel mortar for grinding frozen tissue while retaining low sample temperatures.

Tissue capacity: 100 mg to 10 g · Insulated mortar for manual grinding of frozen tissue

BioSqueezer ↗

A mechanical clamp for compressing and rapidly freezing fresh tissue into a thin wafer for subsequent sample preparation.

Fresh tissue in a poly-bag · Liquid-nitrogen-cooled compression clamp

Tissue Tearor II ↗

A digitally controlled rotor-stator homogenizer for soft tissue, emulsification and liquid sample preparation across a broad range of volumes.

1–1,000 mL, probe dependent · 8,000–35,000 rpm

MicroMincer ↗

A hand-operated stainless steel screw press for small soft-tissue samples and undiluted extracts for downstream analysis.

Manual screw press with a 250 µm screen · Disposable sample liners

CryoMill ↗

Automatic nitrogen cooling for suitable difficult biological or elastic samples.

Confirm jar, adapter and downstream assay compatibility

Q55 Sonicator ↗

Compact manual sonication for routine small-volume cell disruption.

55 W; up to 50 mL · Thumb-switch or continuous output; standard 1/8 in probe

Q125 Sonicator ↗

Programmable small-volume sonication with pulse mode and digital energy monitoring.

125 W; up to 50 mL · 20-100% amplitude; timer up to 10 hours

Q500 Sonicator ↗

Laboratory probe sonication for cell lysis, homogenization and dispersion.

500 W; up to 1 L · 20-100% amplitude; programmable timing and pulses

Q700 Sonicator ↗

Touchscreen sonication with full-range amplitude control and stored program sequences.

700 W; up to 2 L for low-viscosity liquids · 1-100% amplitude; 10 stored programs; sequences of up to 5

Q2000 Sonicator ↗

Industrial ultrasonic processing for larger batches, including cell lysis, with direct-probe or flow-cell configurations.

2,000 W; approximate system range 5-20 L · Programmable timing, pulses and optional temperature monitoring

Q2500 Sonicator ↗

High-power industrial ultrasonic processing for application-dependent large batches.

2,500 W; approximate range 5-20 L · High-intensity probe and booster; optional temperature monitoring

Q800R3 Sonicator ↗

Dedicated cooled system for chromatin and DNA shearing in sealed sample tubes.

750 W; 50 µL to 1 mL per tube · Up to 18 tubes, rack dependent; 150 bp to 3 kb DNA fragment range · Chiller, rotating sample system and sound enclosure included

START WITH YOUR OUTCOME

Select a disruption approach around the biological sample and the work that follows.

What this process can help you do

  • Process cells and biological materials
  • Compare different disruption approaches
  • Prepare samples for downstream work

What guides the selection

  • Sample type and working volume
  • Temperature and handling constraints
  • Downstream sample requirements

TECHNOLOGY & EQUIPMENT

Let’s narrow the technology together.

The appropriate system depends on your sample and desired outcome. Talk with the team to explore current equipment and options.

Start with your application.

Sample type and working volume · Temperature and handling constraints · Downstream sample requirements

Ask an expert

Choosing a biological sample preparation method

BUILD CONFIDENCE

From a question to a practical next step.

01

Understand

Define the material, desired result and operating constraints.

02

Evaluate

Compare promising technologies and agree on an approach.

03

Validate

Test material, assess results and refine the process.

04

Scale

Connect the outcome to lab, pilot or production needs.

BIOLOGICAL SAMPLE PREPARATION

Explore tissue preparation
and cell disruption.

LET’S MOVE YOUR MATERIAL FORWARD

A challenging material.
A conversation away.

Share the result you need. We’ll help you find a practical next step.