Z® RP Cell and Tissue Culturing

Z^® RP bioreactors are easy to assemble and handle. They are usually operated in perfusion mode and host large amounts of cells in very small volumes. The center piece is a magnetic coupled rotating axis mounted with the cell- or tissue carrier of choice exposing cells to medium and overlay alternately.

From highly porous Sponceram^® discs to implant scaffolds all kinds of supports can be installed in a Z^® RP bioreactor giving rise to a vast variety of culturing options. In all configurations best possible aeration and feeding is guaranteed. The gentle rotational motion stimulates cells and tissues to adhere and proliferate fast without being stressed by shear forces. Cell populations stay viable and express large amounts of extracellular matrix. Three-dimensional high density cultivation can be extended to many months without loosing viability or expression productivity. Harvest of adherent cells is easily achieved employing specific rotation programs in combination with detaching solutions.

A Z^® RP GMP Breeder is an innovative supply system combined with a laminar flow functionality. The sterile and temperature controlled workroom protects the Z^® RP bioreactor from contamination and enables the user to conduct all necessary manipulations – e. g. preparation of cell and tissue samples, inoculation, change of medium container, tube change, sensor exchange, cell harvesting – in a sterile and closely controlled environment.

The Z^® RP control unit ensures safe operation of all cell- and tissue culturing processes conducted in Z^® RP bioreactors and Z^® RP GMP Breeders. System configurations and process parameters are easily accessible by the integrated touch screen. All relevant cultivation data are logged and evaluated on a personal computer with our implemented standard software according to GMP standards.