Zellwerk GmbH supplies customized implant blanks from Sponceram® and other materials for research use. Blanks for medical use are in preparation. Implant blanks are easily colonized in our Z® RP Bioreactor equipped with implant-specific holding fixtures. E. g. is a moulded carrier of Sponceram® HA covered by primary chondrocytes embedded in their own collagen matrix. Under appropriate cultivation conditions these chondrocytes express Collagene II and Glucosamine Glucanes in physiological ratios indicating in vivo-like differentiation. Implant blanks made from Sponceram® are ideally suited to generate bone-like structures after colonisation with osteoblasts which calcificate even without addition of specific growth factors.
Skin-like tissue preparations are resulting from our biodegradable protein scaffolds when a spiral-shaped rotating bed is colonized by ceratinocytes within a Z® RP Bioreactor. On request we will offer the described implant blanks and other scaffolds.
The Z® RP cell- and tissue culturing systems establish a unique technological platform for fast and controlled expansion of adherent cells. Complying with GLP, GCP, GTP and GMP standards Z® RP culturing systems enable users to grow cells in very high densities, inducing tissue-like organisation of cells embedded in their own extracellular matrix.
Zellwerk’s Z® RP technology opens up completely new perspectives for regenerative medicine being the ideal tool for expansion and harvesting of primary cells and stem cells. The scope of therapeutical applications also includes tissue engineering and even production of complete implants made from colonized scaffolds. Moreover, the compact Z® RP cultivation system allows cost-efficient production of recombinant biopharmaceuticals, vaccines, vectors e. c. Researchers profit from the variability in culturing configurations speeding up development projects significantly.
